publications


 full list of publications and reviews (updated February 2023)

Redox signaling and metabolism in Alzheimer's disease. Holubiec MI, Gellert M, Hanschmann EM. Front Aging Neurosci. 2022 Nov 3;14:1003721. medline

Thiol Modifications in the Extracellular Space-Key Proteins in Inflammation and Viral Infection. Brücksken KA, Loreto Palacio P, Hanschmann EM.  Front Immunol. 2022 Jun 27;13:932525. medline

Changing Perspectives from Oxidative Stress to Redox Signaling-Extracellular Redox Control in Translational Medicine. Loreto Palacio P, Godoy JR, Aktas O, Hanschmann EM. Antioxidants (Basel). 2022 Jun 16;11(6):1181. 
full article on: medline

Nucleoredoxin Plays a Key Role in the Maintenance of Retinal Pigmented Epithelium Differentiation. Holubiec MI, Romero JI, Urbainsky C, Gellert M, Galeano P, Capani F, Lillig CH, Hanschmann EM. Antioxidants (Basel). 2022 Jun 1;11(6):1106. 
full article on: medline

Cytosolic glutaredoxin 1 is upregulated in AMD and controls retinal pigment epithelial cells proliferation via β-catenin. Hanschmann EM, Wilms C, Falk L, Holubiec MI, Mennel S, Lillig CH, Godoy JR.  Biochem Biophys Res Commun. 2022 Jun 9;618:24-29. 
full article on: medline

GDAP1 loss of function inhibits the mitochondrial pyruvate dehydrogenase complex by altering the actin cytoskeleton. Wolf C, Pouya A, Bitar S, Pfeiffer A, Bueno D, Rojas-Charry L, Arndt S, Gomez-Zepeda D, Tenzer S, Bello FD, Vianello C, Ritz S, Schwirz J, Dobrindt K, Peitz M, Hanschmann EM, Mencke P, Boussaad I, Silies M, Brüstle O, Giacomello M, Krüger R, Methner A.  Commun Biol. 2022
full article on: medline

Cofilin1 oxidation links oxidative distress to mitochondrial demise and neuronal cell death. Hoffmann L, Waclawczyk M, Tang S, Hanschmann EM, Gellert M, Rust M, Culmsee C. CDDIS. 2021
full article on: medline

The intrinsic amyloidogenic propensity of cofilin-1 is aggravated by Cys-80 oxidation: A possible link with neurodegenerative diseases. Kaushik V, Brünnert D, Hanschmann EM, Sharma PK, Anand BG, Kar K, Kateriya S, Goyal P. Biochem Biophys Res Commun. 2021
Redox Enzymes of the Thioredoxin Family as Potential and Novel Markers in Pemphigus. Sliwiak P, Folwarczny E, Didona D, Fink S,  Wiegand C, Hanschmann EM, Hertl M, Hudemann C. Oxidative Medicine and Cellular Longevity. 2021

Thioredoxin 1 is upregulated in the bone and bone marrow following experimental myocardial infarction: evidence for a remote organ response. Godoy JR, Pittrich S, Slavic S, Lillig CH, Hanschmann EM, Erben RG. Histochem Cell Biol. 2021 Jan;155(1):89-99.
full article on: medline

Glutaredoxin 2 Reduces Asthma-Like Acute Airway Inflammation in Mice. Hanschmann EM, Berndt C, Hecker C, Garn H, Bertrams W, Lillig CH, Hudemann C. Front Immunol. 2020 Nov 3;11:561724.
full article on: medline

Thiol switches in membrane proteins - Extracellular redox regulation in cell biology. Lorenzen I, Eble JA, Hanschmann EM. Biol Chem. 2020 Oct 28;402(3):253-269. (Review)
full article on: medline

Paracrine regulation and improvement of beta-cell function by thioredoxin. Hanschmann EM, Petry SF, Eitner S, Maresch CC, Lingwal N, Lillig CH, Linn T. Redox Biology, 2020
full article on: medline

Redox modifications of proteins of the mitochondrial fusion and fission machinery. Wolf C, Lopez Del Amo V, Arndt S, Bueno D, Tenzer S, Hanschmann EM, Berndt C, Methner A. Cells, 2020
full article on: medline

Extracellular redox regulation of a7b1 integrin-mediated cell migration is signaled via a dominant thiol-switch.Bergerhausen L., Grosche J, Meißner J, Hecker C, Caliandro MF, Westerhausen C, Kamenac A, Rezaei M, Mörgelin M, Poschmann G, Vestweber D, Hanschmann EM, Eble JA. Antioxidants (Basel), 2020
full article on: medline

The cytosolic isoform of Glutaredoxin 2 promotes cell migration and invasion.Gellert M, Richter E, Mosterz J, Kantz L, Masur K, Hanschmann EM, Ribback S, Kroeger N, Schaeffler E, Winter S, Hochgräfe F, Schwab M, Lillig CH. Biochim Biophys Acta Gen Subj. 2020
full article on: medline

Thioredoxin 1 Plays a Protective Role in Retinas Exposed to Perinatal Hypoxia-Ischemia.  Holubiec MI, Galeano P, Romero JI, Hanschmann EM, Lillig CH, Capani F. Neuroscience. 2020.
full article on: medline

How the redox state regulates immunity. Mullen L, Mengozzi M, Hanschmann EM, Alberts B, Ghezzi P. Free Radic Biol Med. 2019. Review.
full article on: medline

Signals of the Neuropilin-1-MET Axis and Cues of Mechanical Force Exertion Converge to Elicit Inflammatory Activation in Coherent Endothelial Cells.  Rezaei M, Martins Cavaco AC, Seebach J, Niland S, Zimmermann J, Hanschmann EM, Hallmann R, Schillers H, Eble JA. J Immunol. 2019
full article on medline

Nucleoredoxin-Dependent Targets and Processes in Neuronal Cells. Urbainsky C, Nölker R, Imber M, Lübken A, Mostertz J, Hochgräfe F, Godoy JR, Hanschmann EM*, Lillig CH*. Oxid Med Cell Longev. 2018

Redox Regulation of Inflammatory Processes Is Enzymatically Controlled.  Lorenzen I, Mullen L, Bekeschus S, Hanschmann EM. Oxid Med Cell Longev. 2017

Neuronal Damage Induced by Perinatal Asphyxia Is Attenuated by Postinjury Glutaredoxin-2 Administration. Romero JI, Holubiec MI, Tornatore TL, Rivière S, Hanschmann EM, Kölliker-Frers RA, Tau J, Blanco E, Galeano P, Rodríguez de Fonseca F, Lillig CH, Capani F.
Oxid Med Cell Longev. 2017

Cold Atmospheric Plasma Treatment Induces Anti-Proliferative Effects in Prostate Cancer Cells by Redox and Apoptotic Signaling Pathways. Weiss M, Gümbel D, Hanschmann EM, Mandelkow R, Gelbrich N, Zimmermann U, Walther R, Ekkernkamp A, Sckell A, Kramer A, Burchardt M, Lillig CH, Stope MB. PLoS One. 2015
full article on Plos One

Redox proteomics of the inflammatory secretome identifies a common set of redoxins and other glutathionylated proteins released in inflammation, influenza virus infection and oxidative stress. Checconi P, Salzano S, Bowler L, Mullen L, Mengozzi M, Hanschmann EM, Lillig CH, Sgarbanti R, Panella S, Nencioni L, Palamara AT, Ghezzi P. PLoS One. 2015
full article on Plos One

Thioredoxin 1 and glutaredoxin 2 contribute to maintain the phenotype and integrity of neurons following perinatal asphyxia. Romero JI, Hanschmann EM, Gellert M, Eitner S, Holubiec MI, Blanco-Calvo E, Lillig CH, Capani F. Biochim Biophys Acta. 2015
full article on medline

Cysteine Oxidation Targets Peroxiredoxins 1 and 2 for Exosomal Release through a Novel Mechanism of Redox-Dependent Secretion. Mullen L, Hanschmann EM, Lillig CH, Herzenberg LA, Ghezzi P. Mol Med. 2015
full article on medline

Redox regulation of cytoskeletal dynamics during differentiation and de-differentiation. Gellert M, Hanschmann EM, Lepka K, Berndt C, Lillig CH. Biochim Biophys Acta. 2015
full article on medline

Linkage of inflammation and oxidative stress via release of glutathionylated peroxiredoxin-2, which acts as a danger signal. Salzano S, Checconi P, Hanschmann EM, Lillig CH, Bowler LD, Chan P, Vaudry D, Mengozzi M, Coppo L, Sacre S, Atkuri KR, Sahaf B, Herzenberg LA, Herzenberg LA, Mullen L, Ghezzi P. Proc Natl Acad Sci U S A. 2014
full article on PNAS

Identification of a dithiol-disulfide switch in collapsin response mediator protein 2 (CRMP2) that is toggled in a model of neuronal differentiation. Gellert M, Venz S, Mitlöhner J, Cott C, Hanschmann EM, Lillig CH. J Biol Chem. 2013
full article on JBC

Identification of potential protein dithiol-disulfide substrates of mammalian Grx2. Schütte LD, Baumeister S, Weis B, Hudemann C, Hanschmann EM, Lillig CH. Biochim Biophys Acta. 2013
full article on medline

Crucial function of vertebrate glutaredoxin 3 (PICOT) in iron homeostasis and hemoglobin maturation. Haunhorst P*, Hanschmann EM*, Bräutigam L, Stehling O, Hoffmann B, Mühlenhoff U, Lill R*, Berndt C*, Lillig CH*. Mol Biol Cell. 2013
full article on MBoC

Thioredoxins, glutaredoxins, and peroxiredoxins--molecular mechanisms and health significance: from cofactors to antioxidants to redox signaling.Hanschmann EM, Godoy JR, Berndt C, Hudemann C, Lillig CH. Antioxid Redox Signal.2013
full article on medline

Segment-specific overexpression of redoxins after renal ischemia and reperfusion: protective roles of glutaredoxin 2, peroxiredoxin 3, and peroxiredoxin 6.Godoy JR, Oesteritz S*, Hanschmann EM*, Ockenga W, Ackermann W, Lillig CH. Free Radic Biol Med.2011
full article on medline

Both thioredoxin 2 and glutaredoxin 2 contribute to the reduction of the mitochondrial 2-Cys peroxiredoxin Prx3.Hanschmann EM, Lönn ME, Schütte LD, Funke M, Godoy JR, Eitner S, Hudemann C, Lillig CH. J Biol Chem.2010
full article on JBC

Thioredoxin and glutaredoxin system proteins-immunolocalization in the rat central nervous system.Aon-Bertolino ML, Romero JI, Galeano P, Holubiec M, Badorrey MS, Saraceno GE, Hanschmann EM, Lillig CH, Capani F. Biochim Biophys Acta.2011
full article on medline

Monothiol glutaredoxin-1 is an essential iron-sulfur protein in the mitochondrion of African trypanosomes.Comini MA, Rettig J, Dirdjaja N, Hanschmann EM, Berndt C, Krauth-Siegel RL. J Biol Chem.2008
full article on JBC

How does iron-sulfur cluster coordination regulate the activity of human glutaredoxin 2?Berndt C, Hudemann C, Hanschmann EM, Axelsson R, Holmgren A, Lillig CH. Antioxid Redox Signal.2007
full article on medline